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J14

J14
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Purity:97.81%
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J14

Catalog No. T8320Cas No. 1043854-13-2
J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$42In Stock
5 mg$68In Stock
10 mg$97In Stock
25 mg$158In Stock
50 mg$242In Stock
100 mg$411In Stock
1 mL x 10 mM (in DMSO)$77In Stock
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Product Introduction

Bioactivity
Description
J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death
Targets&IC50
Sulfiredoxin:8.1 μM
AliasJ-14
Chemical Properties
Molecular Weight517.04
FormulaC28H25ClN4O2S
Cas No.1043854-13-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 260 mg/mL (502.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9341 mL9.6704 mL19.3409 mL96.7043 mL
5 mM0.3868 mL1.9341 mL3.8682 mL19.3409 mL
10 mM0.1934 mL0.9670 mL1.9341 mL9.6704 mL
20 mM0.0967 mL0.4835 mL0.9670 mL4.8352 mL
50 mM0.0387 mL0.1934 mL0.3868 mL1.9341 mL
100 mM0.0193 mL0.0967 mL0.1934 mL0.9670 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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