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TAT-GluN2BCTM

Catalog No. T80210Cas No. 1587742-50-4

TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, thereby protecting neurons against oxidative stress and NMDAR-mediated excitotoxicity. This compound's role in facilitating neuroprotection makes it a valuable agent for related research studies [1].

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Product Introduction

Bioactivity

Description	TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, thereby protecting neurons against oxidative stress and NMDAR-mediated excitotoxicity. This compound's role in facilitating neuroprotection makes it a valuable agent for related research studies [1].
In vitro	TAT-GluN2BCTM (200 µM; 0.5, 2, 4 h) reduces the levels of DAPK1 in primary neuronal cultures treated with NMDA in a time-dependent manner [1].
In vivo	Administration of TAT-GluN2BCTM (10 mg/kg; i.v.; single) resulted in a significant decrease in the levels of active DAPK1 in the ischemic hemisphere of the rat brain [1]. TAT-GluN2BCTM demonstrated substantial neuroprotective effects in the cortex and striatum of rats [1]. Furthermore, TAT-GluN2BCTM was able to specifically reduce the activity of the active (but not inactive) form of DAPK1 [1].

Chemical Properties

Molecular Weight	5135.91
Formula	C224H374N86O54
Cas No.	1587742-50-4

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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