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HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $47 | In Stock | |
10 mg | $67 | In Stock | |
25 mg | $138 | In Stock | |
50 mg | $222 | In Stock | |
100 mg | $361 | In Stock | |
200 mg | $538 | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders. |
Targets&IC50 | DAPK1:300 nM (Kd), DAPK1:IC50 : 200 nM, DAPK2:79 nM (Kd), ZIPK:280 nM (Kd), Pim3:200 nM (Kd) |
In vitro | HS38 shows a Kd of 79 nM for DAPK2. In human aortic SM cells, HS38 reduces relative RLC20 phosphorylation in both the basal and S1P-activated states. In Ca2+-sensitized rabbit ileum, HS38 reduces the contractile force, MYPT1 phosphorylation, and RLC20 phosphorylation[1]. |
Alias | HS-38, HS 38 |
Molecular Weight | 349.8 |
Formula | C14H12ClN5O2S |
Cas No. | 1030203-81-6 |
Smiles | CC(Sc1nc2n(ncc2c(=O)[nH]1)-c1cccc(Cl)c1)C(N)=O |
Relative Density. | 1.65 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 6.4 mg/mL (18.4 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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