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HS38

Catalog No. T27554Cas No. 1030203-81-6
Alias HS-38, HS 38

HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.

HS38

HS38

Purity: 95.53%
Catalog No. T27554Alias HS-38, HS 38Cas No. 1030203-81-6
HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$67In Stock
25 mg$138In Stock
50 mg$222In Stock
100 mg$361In Stock
200 mg$538In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Purity:95.53%
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Product Introduction

Bioactivity
Description
HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
Targets&IC50
DAPK1:300 nM (Kd), DAPK1:IC50 : 200 nM, Pim3:200 nM (Kd), ZIPK:280 nM (Kd), DAPK2:79 nM (Kd)
In vitro
HS38 shows a Kd of 79 nM for DAPK2. In human aortic SM cells, HS38 reduces relative RLC20 phosphorylation in both the basal and S1P-activated states. In Ca2+-sensitized rabbit ileum, HS38 reduces the contractile force, MYPT1 phosphorylation, and RLC20 phosphorylation[1].
AliasHS-38, HS 38
Chemical Properties
Molecular Weight349.8
FormulaC14H12ClN5O2S
Cas No.1030203-81-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6.4 mg/mL (18.4 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8588 mL14.2939 mL28.5878 mL142.9388 mL
5 mM0.5718 mL2.8588 mL5.7176 mL28.5878 mL
10 mM0.2859 mL1.4294 mL2.8588 mL14.2939 mL

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