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Arbutamine
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Catalog No. T10364Cas No. 128470-16-6
Alias GP 21213
Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.Arbutamine can be used to study cardiac stress and coronary artery disease
Arbutamine
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Purity: 95.06%
Catalog No. T10364Alias GP 21213Cas No. 128470-16-6
Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.Arbutamine can be used to study cardiac stress and coronary artery disease
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $268 | 6-8 weeks | |
| 1 mg | $397 | In Stock | |
| 5 mg | $970 | In Stock | |
| 10 mg | $1,180 | In Stock |
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Purity:95.06%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.Arbutamine can be used to study cardiac stress and coronary artery disease |
| In vitro | The affinity constants (Ka) of arbutamine and isoproterenol for cardiac beta1-adrenergic receptors, as determined by competition binding assays, were found to be 7.32 and 6.04, respectively[3]. |
| In vivo | In the electrical stimulation of the left atrium of rats, Arbutamine increases contractility. The pD2 values (logarithm of the dose producing 50% of the maximum response) for Arbutamine and isoproterenol are 8.45 +/- 0.15 and 8.55 +/- 0.02, respectively. In the guinea pig trachea, Arbutamine and isoproterenol induced a concentration-dependent relaxation, which was inhibited by propranolol[3]. |
| Alias | GP 21213 |
| Molecular Weight | 317.38 |
| Formula | C18H23NO4 |
| Cas No. | 128470-16-6 |
| Smiles | O[C@@H](CNCCCCc1ccc(O)cc1)c1ccc(O)c(O)c1 |
| Relative Density. | 1.262g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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