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Buflomedil hydrochloride
Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.
Catalog No. T0317Cas No. 35543-24-9
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Purity:99.7%
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Buflomedil hydrochloride
Catalog No. T0317Alias Loftyl, Fonzylane, Buflomedil HClCas No. 35543-24-9
Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $35 | In Stock | |
| 500 mg | $54 | In Stock | |
| 1 g | $78 | In Stock | |
| 5 g | $189 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease. |
| In vitro | Buflomedil enhances intracellular cAMP levels in human keratinocytes, either secondary to adenyl-cyclase stimulation (BC) or phosphodiesterase inhibition (PTX). Buflomedil diminishes release of TPA-induced TNF-alpha and IL-8 in keratinocytes; in the case of IL-8, this inhibition may occur to transcriptional level. At the micromolar level, Buflomedil notably inhibits epinephrine-induced aggregation. Buflomedil leads to a weak inhibition of collagen- and ADP-induced aggregation. Buflomedil inhibits grainy secretion and the interaction of fibrinogen with its receptor on platelet. the capillary perfusion is improved by Buflomedil hypochloride in such related situations, evoking a possible effect upon neutrophils. Buflomedil Completely inhibits adhesion of histamine related neutrophil (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil lowers the hypoxia-induced neutrophil adhesion and expression of P-selectin at the surface of endothelial cells. |
| Alias | Loftyl, Fonzylane, Buflomedil HCl |
| Molecular Weight | 343.85 |
| Formula | C17H26ClNO4 |
| Cas No. | 35543-24-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 7 mg/mL (20.35 mM) H2O: 63 mg/mL (183.2 mM) DMSO: 50 mg/mL (145.41 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO/H2O
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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