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Nigericin

Catalog No. T16323Cas No. 28380-24-7

Nigericin, an antibiotic derived from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It can activate NLRP3 and cause the release of IL-1β in a NALP3-dependent manner. Nigericin induces eryptosis, partly due to oxidative stress and ROS formation, and also causes apoptosis.

Nigericin
Other Forms of Nigericin:
Nigericin sodium saltT309228643-80-3
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Nigericin

Catalog No. T16323Cas No. 28380-24-7
Nigericin, an antibiotic derived from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It can activate NLRP3 and cause the release of IL-1β in a NALP3-dependent manner. Nigericin induces eryptosis, partly due to oxidative stress and ROS formation, and also causes apoptosis.
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Product Introduction

Bioactivity
Description
Nigericin, an antibiotic derived from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It can activate NLRP3 and cause the release of IL-1β in a NALP3-dependent manner. Nigericin induces eryptosis, partly due to oxidative stress and ROS formation, and also causes apoptosis.
Chemical Properties
Molecular Weight724.96
FormulaC40H68O11
Cas No.28380-24-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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