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Nigericin
🥰Excellent
Catalog No. T16323Cas No. 28380-24-7
Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1/GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt/β-catenin signaling downregulation.
Nigericin
🥰Excellent
Catalog No. T16323Cas No. 28380-24-7
Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1/GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt/β-catenin signaling downregulation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $129 | In Stock | |
| 25 mg | $277 | In Stock | |
| 50 mg | $450 | In Stock | |
| 100 mg | $723 | In Stock | |
| 200 mg | $996 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1/GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt/β-catenin signaling downregulation. |
| Targets&IC50 | 4T1 cells:2.505 μM, MDA-MB-231 cells:2.881 μM |
| In vitro | Methods: MDA-MB-231, MDA-MB-468, SK-BR-3, MCF-7 and 4T1 cells were treated with Nigericin (0.25, 0.5, 1, 2, 5, 10 and 20 μg/mL), cell viability was measured by MTS assay, and IC50 values were calculated based on the cell viability curves. Results: Nigericin inhibited the cell viability of MDA-MB-231 and 4T1 cells in a dose-dependent manner, with IC50 values of 2.881 μM and 2.505 μM, respectively. [4] |
| In vivo | Methods: BALB/c mice transplanted with 4T1 cells were treated with Nigericin (2 mg/kg, subcutaneously, every two days for 4 weeks), and tumor volume was monitored every 3 to 4 days. At the end of the experiment, mice were euthanized by carbon dioxide, and tumors were harvested for further analysis. Results: Nigericin inhibited tumor growth. [4] |
| Molecular Weight | 724.96 |
| Formula | C40H68O11 |
| Cas No. | 28380-24-7 |
| Smiles | C[C@H]1[C@]2(O[C@@](C)(C1)[C@@]3(O[C@@](C)(CC3)[C@@]4(O[C@](C[C@@H]4C)([C@]5(O[C@](CO)(O)[C@H](C)C[C@@H]5C)[H])[H])[H])[H])O[C@H](C[C@@H]6O[C@@]([C@H](C(O)=O)C)([C@@H](C)CC6)[H])C[C@@H](OC)[C@H]2C |
| Relative Density. | 1.19 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: < 1 mg/mL (insoluble) Ethanol: 30 mg/mL (41.38 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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