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Tauroursodeoxycholate sodium

🥰Excellent
Catalog No. T6993Cas No. 35807-85-3
Alias TUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholate

Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.

Tauroursodeoxycholate sodium

Tauroursodeoxycholate sodium

🥰Excellent
Purity: 99.78%
Catalog No. T6993Alias TUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholateCas No. 35807-85-3
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
Pack SizePriceAvailabilityQuantity
25 mg$30In Stock
50 mg$42In Stock
100 mg$58In Stock
200 mg$77In Stock
500 mg$119In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:99.78%
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Product Introduction

Bioactivity
Description
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
In vivo
In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]
Cell Research
Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter.
Animal Research
Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection
AliasTUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholate
Chemical Properties
Molecular Weight521.69
FormulaC26H44NNaO6S
Cas No.35807-85-3
Smiles[Na+].CC(CCC(=O)NCCS([O-])(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 10 mg/mL (19.2 mM)
DMSO: 55 mg/mL (105.43 mM)
H2O: 92 mg/mL (176.3 mM)
Solution Preparation Table
Ethanol/DMSO/H2O
1mg5mg10mg50mg
1 mM1.9168 mL9.5842 mL19.1685 mL95.8424 mL
5 mM0.3834 mL1.9168 mL3.8337 mL19.1685 mL
10 mM0.1917 mL0.9584 mL1.9168 mL9.5842 mL
DMSO/H2O
1mg5mg10mg50mg
20 mM0.0958 mL0.4792 mL0.9584 mL4.7921 mL
50 mM0.0383 mL0.1917 mL0.3834 mL1.9168 mL
100 mM0.0192 mL0.0958 mL0.1917 mL0.9584 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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