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(±)14-HDHA
😃Good
Catalog No. T35509Cas No. 87042-40-8
Alias 14-hydroxy Docosahexaenoic acid, (±)14-HDoHE
(±)14-HDHA is a hydroxydocosahexaenoic acid, an oxidized metabolite of DHA generated intracellularly by enzymatic or non-enzymatic reactions, is one of the specific substrates of 15-PGDH and can be further oxidized to the anti-inflammatory 14-oxoDHA, and in primary alveolar macrophages, 14-HDoHE itself significantly inhibits LPS-induced IL-6 mRNA expression in primary alveolar macrophages, which may be relevant to inflammatory diseases such as asthma.
(±)14-HDHA
😃Good
Catalog No. T35509Alias 14-hydroxy Docosahexaenoic acid, (±)14-HDoHECas No. 87042-40-8
(±)14-HDHA is a hydroxydocosahexaenoic acid, an oxidized metabolite of DHA generated intracellularly by enzymatic or non-enzymatic reactions, is one of the specific substrates of 15-PGDH and can be further oxidized to the anti-inflammatory 14-oxoDHA, and in primary alveolar macrophages, 14-HDoHE itself significantly inhibits LPS-induced IL-6 mRNA expression in primary alveolar macrophages, which may be relevant to inflammatory diseases such as asthma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $373 | 35 days | |
| 50 μg | Inquiry | 35 days | |
| 100 μg | Inquiry | 35 days | |
| 250 μg | Inquiry | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (±)14-HDHA is a hydroxydocosahexaenoic acid, an oxidized metabolite of DHA generated intracellularly by enzymatic or non-enzymatic reactions, is one of the specific substrates of 15-PGDH and can be further oxidized to the anti-inflammatory 14-oxoDHA, and in primary alveolar macrophages, 14-HDoHE itself significantly inhibits LPS-induced IL-6 mRNA expression in primary alveolar macrophages, which may be relevant to inflammatory diseases such as asthma. |
| Alias | 14-hydroxy Docosahexaenoic acid, (±)14-HDoHE |
| Molecular Weight | 344.49 |
| Formula | C22H32O3 |
| Cas No. | 87042-40-8 |
| Smiles | C(\C(C/C=C\C/C=C\CC)O)=C/C=C\C/C=C\C/C=C\CCC(O)=O |
| Relative Density. | 0.995 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | PBS (pH 7.2): < 1 mg/mL (insoluble), Sonication is recommended. DMF: Miscible Ethanol: Miscible 0.1 M Na2CO3: 1 mg/mL (2.9 mM), Sonication is recommended. DMSO: Miscible | ||||||||||
Solution Preparation Table | |||||||||||
0.1 M Na2CO3
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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