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Erinacine A
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Catalog No. TN7240Cas No. 156101-08-5
Alias (+)-Erinacin A
Erinacine A ((+)-Erinacin A) is a cyanoalkane diterpene extracted from Monkey Head Fungus, a neuroprotective agent with anticancer activity. (+)-Erinacin A induces apoptosis, reduced proliferation, invasiveness, oxidative stress production and cell cycle arrest in cancer cells.
Erinacine A
😃Good
Catalog No. TN7240Alias (+)-Erinacin ACas No. 156101-08-5
Erinacine A ((+)-Erinacin A) is a cyanoalkane diterpene extracted from Monkey Head Fungus, a neuroprotective agent with anticancer activity. (+)-Erinacin A induces apoptosis, reduced proliferation, invasiveness, oxidative stress production and cell cycle arrest in cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,060 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Erinacine A ((+)-Erinacin A) is a cyanoalkane diterpene extracted from Monkey Head Fungus, a neuroprotective agent with anticancer activity. (+)-Erinacin A induces apoptosis, reduced proliferation, invasiveness, oxidative stress production and cell cycle arrest in cancer cells. |
| In vitro | 30 μM Erinacine A, treated for 3-24 hours, activated exogenous and endogenous apoptosis (apoptotic) pathways in DLD-1 cells, while down-regulating the expression levels of anti-apoptotic proteins. [1] |
| In vivo | In a SAM rat model of transient stroke, single-dose intraperitoneal injections of Erinacine A (1, 5, and 10 mg/kg) reduced neuronal cell death and inhibited the expression of inflammatory cytokines in brain tissue. [1] Erinacine A (1, 2, and 5 mg/kg, intraperitoneal injection once daily for 5 days) significantly inhibited tumor growth in a DLD-1 xenograft mouse model, resulting in a significant reduction in tumor size. [2] |
| Alias | (+)-Erinacin A |
| Molecular Weight | 432.55 |
| Formula | C25H36O6 |
| Cas No. | 156101-08-5 |
| Smiles | C[C@]12C(C=3[C@](C)([C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)CC(C=O)=CC3)CC1)=C(C(C)C)CC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | Ethanol: 8 mg/mL (18.49 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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