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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $43 | In Stock | |
5 mg | $93 | In Stock | |
10 mg | $166 | In Stock | |
25 mg | $277 | In Stock | |
50 mg | $397 | In Stock | |
100 mg | $597 | In Stock | |
1 mL x 10 mM (in DMSO) | $95 | In Stock |
Description | GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM |
In vitro | The effect of GSK3179106 on human and rat RET enzymatic activity and motesanib on human RET enzymatic activity was determined in an in vitro biochemical homogeneous time-resolved fluorescence (HTRF) assay. |
In vivo | GSK3179106 (3 or 10 mg/kg; orally; for 3.5 days BID) reduces the visceromotor response (VMR) in comparison to rats given an acetic acid enema and dosed with vehicle. |
Molecular Weight | 467.41 |
Formula | C22H21F4N3O4 |
Cas No. | 1627856-64-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (213.94 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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