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Z-LEHD-fmk

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Z-LEHD-fmk

Catalog No. T21835Cas No. 210345-04-3

Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of Bubalus bubalis and alters the cellular stress response.

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Pack Size	Price	Availability
1 mg	$198	In Stock
5 mg	$619	In Stock
10 mg	$877	In Stock
25 mg	$1,280	In Stock
50 mg	$1,750	In Stock

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Product Introduction

Bioactivity

Description	Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of Bubalus bubalis and alters the cellular stress response.
In vitro	Pretreated for 30 minutes at a concentration of 20 μM, Z-LEHD-FMK completely protects HCT116 and 293 cells from TRAIL-induced toxicity[1]. Additionally, at a concentration of 20 μM for 6 hours, Z-LEHD-FMK protects normal human hepatocytes from TRAIL-induced apoptosis[1].
In vivo	In spinal cord injury (SCI) rats, Z-LEHD-FMK administered intravenously at a dose of 0.8 μmol/kg for 7 days protects neurons, glia, myelin, axons, and intracellular organelles[3].

Chemical Properties

Molecular Weight	690.72
Formula	C32H43FN6O10
Cas No.	210345-04-3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (130.30 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4478 mL	7.2388 mL	14.4776 mL	72.3882 mL
5 mM	0.2896 mL	1.4478 mL	2.8955 mL	14.4776 mL
10 mM	0.1448 mL	0.7239 mL	1.4478 mL	7.2388 mL
20 mM	0.0724 mL	0.3619 mL	0.7239 mL	3.6194 mL
50 mM	0.0290 mL	0.1448 mL	0.2896 mL	1.4478 mL
100 mM	0.0145 mL	0.0724 mL	0.1448 mL	0.7239 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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