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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 values of 0.069, 0.097 and 0.127 μM against hAChE, hBACE-1 and hBChE, respectively. AChE/BChE/BACE-1-IN-2 shows potential disassembly of Aβ aggregates and neuroprotective activity against Aβ-induced stress with excellent brain permeation [1]. |
In vivo | Compound 4o (AChE/BChE/BACE-1-IN-2) administered orally at dosages ranging from 0 to 10 mg/kg, effectively ameliorates cognitive dysfunction in a scopolamine-induced amnesia model, as demonstrated in the Y-maze test [1]. |
Molecular Weight | 302.36 |
Formula | C18H20F2N2 |
Cas No. | 1877000-20-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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