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McN-A 343

McN-A 343
McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental models of ulcerative colitis.
Catalog No. T22963Cas No. 55-45-8
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Purity:99.82%
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McN-A 343

Catalog No. T22963Cas No. 55-45-8
McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental models of ulcerative colitis.
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50 mg$79In Stock
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Product Introduction

Bioactivity
Description
McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental models of ulcerative colitis.
In vivo
After the induction of 6% acetic acid colitis, treatment with McN-A 343 at a concentration of 1.5 mg/kg showed a significant reduction in intestinal damage as well as a decrease in wet weight, MPO activity, pro-inflammatory cytokine concentration, markers of oxidative stress and expression of inflammatory mediator[2].
Chemical Properties
Molecular Weight317.21
FormulaC14H18Cl2N2O2
Cas No.55-45-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (283.7 mM), Sonication is recommended.
H2O: < 31.72 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1525 mL15.7624 mL31.5249 mL157.6243 mL
5 mM0.6305 mL3.1525 mL6.3050 mL31.5249 mL
10 mM0.3152 mL1.5762 mL3.1525 mL15.7624 mL
20 mM0.1576 mL0.7881 mL1.5762 mL7.8812 mL
50 mM0.0630 mL0.3152 mL0.6305 mL3.1525 mL
100 mM0.0315 mL0.1576 mL0.3152 mL1.5762 mL

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