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TT01001

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Purity:100%

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TT01001

Catalog No. T24905Cas No. 1022367-69-6

TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.

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Pack Size	Price	Availability
1 mg	$119	In Stock
2 mg	$178	In Stock
5 mg	$273	In Stock
10 mg	$398	In Stock
25 mg	$665	In Stock
50 mg	$947	In Stock
100 mg	$1,280	In Stock
500 mg	$2,570	In Stock

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Product Introduction

Bioactivity

Description	TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.
In vivo	In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III[2].
Alias	TT-01001, TT 01001, Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate

Chemical Properties

Molecular Weight	376.3
Formula	C15H19Cl2N3O2S
Cas No.	1022367-69-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (146.16 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6575 mL	13.2873 mL	26.5745 mL	132.8727 mL
5 mM	0.5315 mL	2.6575 mL	5.3149 mL	26.5745 mL
10 mM	0.2657 mL	1.3287 mL	2.6575 mL	13.2873 mL
20 mM	0.1329 mL	0.6644 mL	1.3287 mL	6.6436 mL
50 mM	0.0531 mL	0.2657 mL	0.5315 mL	2.6575 mL
100 mM	0.0266 mL	0.1329 mL	0.2657 mL	1.3287 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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