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Ebselen derivative 1

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Catalog No. T86336Cas No. 3030492-59-9

Ebselen derivative 1 (Compound 19), an orally active glutathione peroxidase (GPx) mimic, exhibits notable protective effects against cisplatin-induced hair cell (HC) damage in both in vitro and in vivo settings. It significantly reduces oxidative stress, apoptosis, and ferroptosis in hair cells, making it useful in the study of cisplatin-induced hearing loss [1].

Ebselen derivative 1

Ebselen derivative 1

😃Good
Catalog No. T86336Cas No. 3030492-59-9
Ebselen derivative 1 (Compound 19), an orally active glutathione peroxidase (GPx) mimic, exhibits notable protective effects against cisplatin-induced hair cell (HC) damage in both in vitro and in vivo settings. It significantly reduces oxidative stress, apoptosis, and ferroptosis in hair cells, making it useful in the study of cisplatin-induced hearing loss [1].
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Product Introduction

Bioactivity
Description
Ebselen derivative 1 (Compound 19), an orally active glutathione peroxidase (GPx) mimic, exhibits notable protective effects against cisplatin-induced hair cell (HC) damage in both in vitro and in vivo settings. It significantly reduces oxidative stress, apoptosis, and ferroptosis in hair cells, making it useful in the study of cisplatin-induced hearing loss [1].
In vitro
Ebselen derivative 1 (Compound 19) (100 μM) significantly reduced cisplatin-induced apoptosis and ferroptosis in hair cells and alleviated the surge of oxidative stress triggered by cisplatin throughout the cochlea [1].
In vivo
Ebselen derivative 1 (Compound 19) administered orally at 80 mg/kg once daily for one week in C57BL/6 mice exhibits hearing protective effects and mitigates hair cell loss induced by cisplatin (5 mg/kg; intraperitoneally administered on the third and seventh days of Ebselen derivative 1 treatment) [1].
Chemical Properties
Molecular Weight305.19
FormulaC13H10N2O2Se
Cas No.3030492-59-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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