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JNJ-28583113

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Catalog No. T74779Cas No. 2765255-93-2
Alias JNJ28583113

JNJ-28583113 is a brain-penetrant TRPM2 antagonist that induces phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death. It inhibits microglia response to pro-inflammatory stimuli, used in the study of neurological diseases.

JNJ-28583113

JNJ-28583113

🥰Excellent
Purity: 98.57%
Catalog No. T74779Alias JNJ28583113Cas No. 2765255-93-2
JNJ-28583113 is a brain-penetrant TRPM2 antagonist that induces phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death. It inhibits microglia response to pro-inflammatory stimuli, used in the study of neurological diseases.
Pack SizePriceAvailabilityQuantity
1 mg$87In Stock
5 mg$209In Stock
10 mg$312In Stock
25 mg$488In Stock
50 mg$846In Stock
100 mg$1,460In Stock
200 mg$1,970In Stock
1 mL x 10 mM (in DMSO)$218In Stock
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Purity:98.57%
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Product Introduction

Bioactivity
Description
JNJ-28583113 is a brain-penetrant TRPM2 antagonist that induces phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death. It inhibits microglia response to pro-inflammatory stimuli, used in the study of neurological diseases.
Targets&IC50
TRPM2 (rat):25 nM, TRPM2 (human):126 nM
In vitro
JNJ-28583113 is a potent TRPM2 antagonist, blocking TRPM2 leads to phosphorylation of GSK3α and β subunits. JNJ-28583113 blocks TRPM2 in chimpanzees, rats, and humans with IC50 values of 100 nM, 25 nM, and 126 nM, respectively. [1]
In vivo
JNJ-28583113 (10 mg/kg, injected subcutaneously) is brain permeable, reaches 400 ng/ml in the brain compartment, and is rapidly metabolized in plasma. [1]
AliasJNJ28583113
Chemical Properties
Molecular Weight366.38
FormulaC19H21F3N2O2
Cas No.2765255-93-2
SmilesO=C(OCC)CN1N=C(C=2C=CC(=CC2)C(F)(F)F)C3=C1CCCCC3
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (218.35 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7294 mL13.6470 mL27.2941 mL136.4703 mL
5 mM0.5459 mL2.7294 mL5.4588 mL27.2941 mL
10 mM0.2729 mL1.3647 mL2.7294 mL13.6470 mL
20 mM0.1365 mL0.6824 mL1.3647 mL6.8235 mL
50 mM0.0546 mL0.2729 mL0.5459 mL2.7294 mL
100 mM0.0273 mL0.1365 mL0.2729 mL1.3647 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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