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Catechin-7-O-xyloside

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Catalog No. TN5440Cas No. 42830-48-8
Alias Catechin 7-O-β-D-xylopyranoside

Catechin-7-O-xyloside(C7Ox) has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.

Catechin-7-O-xyloside

Catechin-7-O-xyloside

😃Good
Catalog No. TN5440Alias Catechin 7-O-β-D-xylopyranosideCas No. 42830-48-8
Catechin-7-O-xyloside(C7Ox) has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.
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Product Introduction

Bioactivity
Description
Catechin-7-O-xyloside(C7Ox) has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.
In vitro
C7Ox treatment induced cell death and decreased plasma membrane integrity, an event typical of apoptosis. C7Ox-induced apoptosis was associated with the proteolytic activation of caspase-6, cleavage of poly(ADP-ribose) polymerase (PARP) and loss of mitochondrial membrane potential. C7Ox also induced the endoplasmic reticulum (ER) stress-regulated pro-apoptotic transcription factor CHOP. The suppression of CHOP expression significantly decreased C7Ox-induced cell death, LDH leakage and caspase-6 activation[1].
In vivo
Antitumor effects, evaluated based on protracted tumor regression, were observed when nude-mice bearing H1299 xenografts were treated with C7Ox. C7Ox-induced tumor regression was accompanied by enhanced expression of CHOP mRNA[1].
AliasCatechin 7-O-β-D-xylopyranoside
Chemical Properties
Molecular Weight422.38
FormulaC20H22O10
Cas No.42830-48-8
SmilesOC1=C2C(O[C@@H]([C@@H](O)C2)C3=CC(O)=C(O)C=C3)=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)=C1
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

Catechin-7-O-xylosideCatechin 7-O-beta-D-xylopyranosideCatechin 7-O-b-D-xylopyranoside
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