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Miro1 Reducer

Name: Miro1 Reducer
Brand: TargetMol
SKU: T35670
Rating: 4.5 (1 reviews)

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Catalog No. T35670Cas No. 2624336-91-8

Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Miro1 Reducer

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Catalog No. T35670Cas No. 2624336-91-8

Pack Size	Price	Availability	Quantity
10 mg	$1,289	Backorder
50 mg	$1,980	Backorder

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Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	425.85
Formula	C₂₀H₁₇FN₇OCl
Cas No.	2624336-91-8
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 42.58 mg/mL (99.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3482 mL	11.7412 mL	23.4824 mL	117.4122 mL
5 mM	0.4696 mL	2.3482 mL	4.6965 mL	23.4824 mL
10 mM	0.2348 mL	1.1741 mL	2.3482 mL	11.7412 mL
20 mM	0.1174 mL	0.5871 mL	1.1741 mL	5.8706 mL
50 mM	0.0470 mL	0.2348 mL	0.4696 mL	2.3482 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Miro-1 ReducerMiro1 Reducer