Shopping Cart

Remove All

Your shopping cart is currently empty

GCN2iB

Select Batch

Purity:99.08%

Resource Download

COA HNMR HPLC

GCN2iB

Catalog No. T11375Cas No. 2183470-12-2

GCN2iB, an ATP-competitive inhibitor of general control nonderepressible 2 (GCN2), exhibits an IC50 of 2.4 nM.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$77	In Stock
5 mg	$178	In Stock
10 mg	$288	In Stock
25 mg	$576	In Stock
50 mg	$825	In Stock
100 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "GCN2iB"

Product Introduction

Bioactivity

Description	GCN2iB, an ATP-competitive inhibitor of general control nonderepressible 2 (GCN2), exhibits an IC50 of 2.4 nM.
Targets&IC50	GCN2:2.4 nM
In vitro	GCN2iB shows an IC50 value of 2.4 nM for GCN2 and potent cellular activity. In a panel of 468 kinases, only GCN2 shows >99.5% inhibition, and three kinases (MAP2K5, STK10, and ZAK) show >95%inhibition at 1 μM GCN2iB, demonstrating high kinase selectivity.
In vivo	In the antitumor activity study of CCRF-CEM xenografts, neither ASNase nor GCN2iB alone significantly affects tumor growth. However, their combination elicits potent antitumor activity (P=0.0002) with synergistic effects. In MV-4-11 and SU.86.86 xenografts, the combination also shows robust antitumor activity with synergistic effects. Tumors treated with ASNase/GCN2iB do not show significant growth even after drug cessation.

Chemical Properties

Molecular Weight	451.83
Formula	C18H12ClF2N5O3S
Cas No.	2183470-12-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (121.73 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2132 mL	11.0661 mL	22.1322 mL	110.6611 mL
5 mM	0.4426 mL	2.2132 mL	4.4264 mL	22.1322 mL
10 mM	0.2213 mL	1.1066 mL	2.2132 mL	11.0661 mL
20 mM	0.1107 mL	0.5533 mL	1.1066 mL	5.5331 mL
50 mM	0.0443 mL	0.2213 mL	0.4426 mL	2.2132 mL
100 mM	0.0221 mL	0.1107 mL	0.2213 mL	1.1066 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc