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TTA-Q6

🥰Excellent
Catalog No. T13219Cas No. 910484-28-5

TTA-Q6, a selective T-type Ca2+ channel antagonist, exhibits potential antitumor and immunomodulatory activities for treating neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cells, thereby inducing intracellular calcium deficiency and endoplasmic reticulum (ER) stress.

TTA-Q6

TTA-Q6

🥰Excellent
Purity: 99.97%
Catalog No. T13219Cas No. 910484-28-5
TTA-Q6, a selective T-type Ca2+ channel antagonist, exhibits potential antitumor and immunomodulatory activities for treating neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cells, thereby inducing intracellular calcium deficiency and endoplasmic reticulum (ER) stress.
Pack SizePriceAvailabilityQuantity
1 mg$58In Stock
1 mL x 10 mM (in DMSO)$125In Stock
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Purity:99.97%
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Product Introduction

Bioactivity
Description
TTA-Q6, a selective T-type Ca2+ channel antagonist, exhibits potential antitumor and immunomodulatory activities for treating neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cells, thereby inducing intracellular calcium deficiency and endoplasmic reticulum (ER) stress.
In vitro
In the acidic tumor microenvironment, TTA-Q6 is released, disrupting cancer cell calcium uptake, inducing endoplasmic reticulum stress, and promoting the translocation of calcium-binding proteins to the cell surface[1].
Chemical Properties
Molecular Weight405.8
FormulaC20H15ClF3N3O
Cas No.910484-28-5
SmilesFC(F)(F)CN1C(=O)Nc2ccc(Cl)cc2[C@]1(C1CC1)c1ccc(cc1)C#N
Relative Density.1.47 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (246.43 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4643 mL12.3213 mL24.6427 mL123.2134 mL
5 mM0.4929 mL2.4643 mL4.9285 mL24.6427 mL
10 mM0.2464 mL1.2321 mL2.4643 mL12.3213 mL
20 mM0.1232 mL0.6161 mL1.2321 mL6.1607 mL
50 mM0.0493 mL0.2464 mL0.4929 mL2.4643 mL
100 mM0.0246 mL0.1232 mL0.2464 mL1.2321 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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