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E235

Name: E235
Brand: TargetMol
SKU: T78077
Price: -1 EUR
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78077Cas No. 891894-69-2

Alias E-235, E 235

E235 is a regulatory activator of transcription factor 4 (ATF4) with antiproliferative activity.E235 acts by initiating the integrated stress response (ISR) and signaling the DNA damage response.

E235

🥰Excellent

Purity: 98.85%

Catalog No. T78077Alias E-235, E 235Cas No. 891894-69-2

E235 is a regulatory activator of transcription factor 4 (ATF4) with antiproliferative activity.E235 acts by initiating the integrated stress response (ISR) and signaling the DNA damage response.

Pack Size	Price	Availability	Quantity
1 mg	65 €	In Stock
5 mg	Inquiry	In Stock

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Purity:98.85%

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COA HNMR LCMS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	E235 is a regulatory activator of transcription factor 4 (ATF4) with antiproliferative activity.E235 acts by initiating the integrated stress response (ISR) and signaling the DNA damage response.
In vitro	In HT1080, B16F10, and AG1522 cells, E235 (0, 1, 5, and 10 µM; 4 hours) increased ATF4 expression in a dose-dependent manner[1].
Alias	E-235, E 235

Chemical Properties

Molecular Weight	484.59
Formula	C₂₈H₂₅FN₄OS
Cas No.	891894-69-2
Smiles	O=C(NC1CCN(CC=2C=CC=CC2)CC1)C3=CC=C4C(SC5=NC(=CN54)C=6C=CC(F)=CC6)=C3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (Insoluble)

DMSO: 5 mg/mL (10.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0636 mL	10.3180 mL	20.6360 mL	103.1800 mL
5 mM	0.4127 mL	2.0636 mL	4.1272 mL	20.6360 mL
10 mM	0.2064 mL	1.0318 mL	2.0636 mL	10.3180 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ATF4