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L-365260
L-365260 is an orally available, selective and potent nonpeptide gastrin and cerebral cholecystokinin receptor (CCK-B) antagonist.L-365260 inhibits CCK-8S-induced increase in [Ca2+]i, blocks stress-induced hypersensitivity in viscera, and blocks the anti-exploratory effect of CCK-4.L-365260 has been used in the study of neurological Ojibwa and endocrine diseases.
Catalog No. T22895Cas No. 118101-09-0
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Purity:99.75%
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L-365260
Catalog No. T22895Alias L365260, L-365,260, L 365260Cas No. 118101-09-0
L-365260 is an orally available, selective and potent nonpeptide gastrin and cerebral cholecystokinin receptor (CCK-B) antagonist.L-365260 inhibits CCK-8S-induced increase in [Ca2+]i, blocks stress-induced hypersensitivity in viscera, and blocks the anti-exploratory effect of CCK-4.L-365260 has been used in the study of neurological Ojibwa and endocrine diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $199 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-365260 is an orally available, selective and potent nonpeptide gastrin and cerebral cholecystokinin receptor (CCK-B) antagonist.L-365260 inhibits CCK-8S-induced increase in [Ca2+]i, blocks stress-induced hypersensitivity in viscera, and blocks the anti-exploratory effect of CCK-4.L-365260 has been used in the study of neurological Ojibwa and endocrine diseases. |
| Targets&IC50 | Gastrin/CCK-B:2.0 nM (Ki), Gastrin:1.9 nM (Ki) |
| In vitro | L-365260 is a compound with high affinity for CCK-B receptors in the brains of various species, which significantly attenuates CCK8S- and CCK4-mediated neuronal depolarization, and has lower affinity for CCK-B and gastrin receptors in dog tissues[1]. |
| In vivo | In male Sprague-Dawley rats (300-350 g), L-365260 (0.01, 0.05, 0.1, 0.2, 0.75, 1.0, 10.0 mg/kg; subcutaneous injection) enhances the analgesic effects[3]. |
| Alias | L365260, L-365,260, L 365260 |
| Molecular Weight | 398.46 |
| Formula | C24H22N4O2 |
| Cas No. | 118101-09-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: <39.85 mg/mL DMSO: 80 mg/mL (200.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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