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Cysmethynil
Catalog No. T36082Cas No. 851636-83-4
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.
Cysmethynil
Catalog No. T36082Cas No. 851636-83-4
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 2 mg | $55 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $143 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | $463 | In Stock | |
| 100 mg | $745 | In Stock | |
| 500 mg | $1,490 | In Stock |
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours. |
| In vitro | Mouse embryonic fibroblasts grown in medium containing 8% serum were treated with concentrations of 15, 20, or 30 μM of Cysmethynil. The medium and drug were changed daily, and cell growth was monitored for 6 days,The results showed that treatment with Cysmethynil led to dose-dependent inhibition of growth in wild-type cells, while Icmt–/– cells were largely unaffected[1]. |
| In vivo | Cysmethynil(20 mg/kg; intraperitoneal injection; three times per week; 2 weeks) used alone or in combination with Paclitaxel/Doxorubicin) significantly inhibits tumor growth. In a xenograft mouse model, Cysmethynil sensitizes cervical cancer cells to chemotherapy drugs[3]. |
| Molecular Weight | 376.53 |
| Formula | C25H32N2O |
| Cas No. | 851636-83-4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMF: 3.3 mg/mL DMSO: 2 mg/mL (5.31 mM), Sonication is recommended. Ethanol: 20 mg/mL | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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