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Cysmethynil

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Purity:99%

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COA HNMR HPLC

Cysmethynil

Catalog No. T36082Cas No. 851636-83-4

Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.

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Pack Size	Price	Availability
1 mg	$39	In Stock
2 mg	$55	In Stock
5 mg	$89	In Stock
10 mg	$143	In Stock
25 mg	$289	In Stock
50 mg	$463	In Stock
100 mg	$745	In Stock
500 mg	$1,490	In Stock

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Product Introduction

Bioactivity

Description	Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.
In vitro	Mouse embryonic fibroblasts grown in medium containing 8% serum were treated with concentrations of 15, 20, or 30 μM of Cysmethynil. The medium and drug were changed daily, and cell growth was monitored for 6 days,The results showed that treatment with Cysmethynil led to dose-dependent inhibition of growth in wild-type cells, while Icmt–/– cells were largely unaffected[1].
In vivo	Cysmethynil(20 mg/kg; intraperitoneal injection; three times per week; 2 weeks) used alone or in combination with Paclitaxel/Doxorubicin) significantly inhibits tumor growth. In a xenograft mouse model, Cysmethynil sensitizes cervical cancer cells to chemotherapy drugs[3].

Chemical Properties

Molecular Weight	376.53
Formula	C25H32N2O
Cas No.	851636-83-4

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 3.3 mg/mL

DMSO: 2 mg/mL (5.31 mM)

Ethanol: 20 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2656 mL	1.3279 mL	2.6558 mL	13.2792 mL
20 mM	0.1328 mL	0.6640 mL	1.3279 mL	6.6396 mL
50 mM	0.0531 mL	0.2656 mL	0.5312 mL	2.6558 mL
100 mM	0.0266 mL	0.1328 mL	0.2656 mL	1.3279 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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