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Rasarfin

Name: Rasarfin
Brand: TargetMol
SKU: T9407
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Rasarfin inhibits Ras and ARF6.

Catalog No. T9407Cas No. 674359-73-0

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Purity:97.98%

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Rasarfin

Catalog No. T9407Cas No. 674359-73-0

Rasarfin inhibits Ras and ARF6.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$73	In Stock
10 mg	$118	In Stock
25 mg	$215	In Stock
50 mg	$358	In Stock
100 mg	$511	In Stock
200 mg	$689	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Product Introduction

Bioactivity

Description

Rasarfin inhibits Ras and ARF6.

In vitro

Rasarfin resulted in a dose-dependent reduction in cell growth in MDA-MB-231 cells.After 48 and 72?h of treatment, Rasarfin modestly decreased in a dose-dependent manner the metabolic activity of cancer cells compared to cells treated with DMSO.However, compared to Doxorubicin which potently killed cells, cell viability was not affected by Rasarfin treatment. Rasarfin inhibited proliferation of A549 lung cancer cells, which have increased Ras and EGFR activity52. Similar to the anti-proliferative effect on MDA-MB-231 cells, A549 cell growth inhibition at 5 and 10?μM of Rasarfin,more important cell viability effects of Rasarfin on A549 cells than MDA-MB-231 cells at 10?μM of Rasarfin treatment[1].

Chemical Properties

Molecular Weight	425.91
Formula	C₂₃H₂₄ClN₃O₃
Cas No.	674359-73-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (140.87 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3479 mL	11.7396 mL	23.4791 mL	117.3957 mL
5 mM	0.4696 mL	2.3479 mL	4.6958 mL	23.4791 mL
10 mM	0.2348 mL	1.1740 mL	2.3479 mL	11.7396 mL
20 mM	0.1174 mL	0.5870 mL	1.1740 mL	5.8698 mL
50 mM	0.0470 mL	0.2348 mL	0.4696 mL	2.3479 mL
100 mM	0.0235 mL	0.1174 mL	0.2348 mL	1.1740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc