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HG-10-102-01

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Purity:99.73%

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COA LCMS HNMR

HG-10-102-01

Catalog No. T7196Cas No. 1351758-81-0

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).

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Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$89	In Stock
10 mg	$143	In Stock
25 mg	$289	In Stock
50 mg	$463	In Stock
100 mg	$668	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
In vivo	HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells.?When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.

Chemical Properties

Molecular Weight	377.83
Formula	C17H20ClN5O3
Cas No.	1351758-81-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (132.33 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6467 mL	13.2335 mL	26.4669 mL	132.3346 mL
5 mM	0.5293 mL	2.6467 mL	5.2934 mL	26.4669 mL
10 mM	0.2647 mL	1.3233 mL	2.6467 mL	13.2335 mL
20 mM	0.1323 mL	0.6617 mL	1.3233 mL	6.6167 mL
50 mM	0.0529 mL	0.2647 mL	0.5293 mL	2.6467 mL
100 mM	0.0265 mL	0.1323 mL	0.2647 mL	1.3233 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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HG-10-102-01