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GNE0877

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Purity:99.96%

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COA LCMS HNMR HPLC

GNE0877

Catalog No. T6031Cas No. 1374828-69-9

GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).

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Pack Size	Price	Availability
1 mg	$39	In Stock
2 mg	$55	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$396	In Stock
50 mg	$592	In Stock
100 mg	$845	In Stock
500 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Product Introduction

Bioactivity

Description	GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
In vitro	Within BAC transgenic mice expressing human LRRK2 protein with the Parkinson's disease mutation G2019S, GNE-0877 effectively inhibits LRRK2 Ser1292 autophosphorylation. GNE-0877 demonstrates favorable oral bioavailability and brain penetrance.
In vivo	GNE-0877 significantly inhibits LRRK2 cellular activity (IC50: 3 nM) and demonstrates low turnover in human liver microsomes and hepatocytes. Additionally, GNE-0877 acts as a reversible inhibitor of CYP1A2 (IC50: 0.7 μM).
Alias	GNE 0877, GNE-0877

Chemical Properties

Molecular Weight	339.32
Formula	C14H16F3N7
Cas No.	1374828-69-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (132.62 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9471 mL	14.7354 mL	29.4707 mL	147.3535 mL
5 mM	0.5894 mL	2.9471 mL	5.8941 mL	29.4707 mL
10 mM	0.2947 mL	1.4735 mL	2.9471 mL	14.7354 mL
20 mM	0.1474 mL	0.7368 mL	1.4735 mL	7.3677 mL
50 mM	0.0589 mL	0.2947 mL	0.5894 mL	2.9471 mL
100 mM	0.0295 mL	0.1474 mL	0.2947 mL	1.4735 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc