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CZC-54252 hydrochloride

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Purity:98.21%

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COA HNMR LCMS

CZC-54252 hydrochloride

Catalog No. T39202Cas No. 1784253-05-9

CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.

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Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$73	In Stock
10 mg	$118	In Stock
25 mg	$228	In Stock
50 mg	$378	In Stock
100 mg	$559	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$100	In Stock

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Product Introduction

Bioactivity

Description	CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
In vitro	CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay[2].

Chemical Properties

Molecular Weight	541.45
Formula	C22H26Cl2N6O4S
Cas No.	1784253-05-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (55.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8469 mL	9.2345 mL	18.4689 mL	92.3446 mL
5 mM	0.3694 mL	1.8469 mL	3.6938 mL	18.4689 mL
10 mM	0.1847 mL	0.9234 mL	1.8469 mL	9.2345 mL
20 mM	0.0923 mL	0.4617 mL	0.9234 mL	4.6172 mL
50 mM	0.0369 mL	0.1847 mL	0.3694 mL	1.8469 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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