Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 91.00 | |
10 mg | In stock | $ 143.00 | |
25 mg | In stock | $ 279.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 728.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 119.00 |
Description | CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM. |
Targets&IC50 | LRRK2 (wild-type):1.28 nM (IC50), LRRK2 (G2019S):1.85 nM (IC50) |
In vitro | CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay[2]. |
Molecular Weight | 541.45 |
Formula | C22H26Cl2N6O4S |
CAS No. | 1784253-05-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (55.41 mM), Sonification and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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