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Ladostigil
🥰Excellent
Catalog No. T32535Cas No. 209394-27-4
Alias TV-3326, TV3326, TV 3326, Ladostigil free base, Ladostigil
Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respectively.Ladostigil possesses anti-inflammatory, antioxidant, and neuroprotective activities, and may be used in studies of depression and Alzheimer's disease.
Ladostigil
🥰Excellent
Purity: 98.79%
Catalog No. T32535Alias TV-3326, TV3326, TV 3326, Ladostigil free base, LadostigilCas No. 209394-27-4
Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respectively.Ladostigil possesses anti-inflammatory, antioxidant, and neuroprotective activities, and may be used in studies of depression and Alzheimer's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $120 | In Stock | |
| 5 mg | $290 | In Stock | |
| 10 mg | $440 | In Stock | |
| 25 mg | $728 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,390 | In Stock | |
| 500 mg | $2,770 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $277 | In Stock |
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Purity:98.79%
ee:98.58%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respectively.Ladostigil possesses anti-inflammatory, antioxidant, and neuroprotective activities, and may be used in studies of depression and Alzheimer's disease. |
| Targets&IC50 | MAO-B:37.1 μM, AChE:31.8 μM |
| In vitro | Ladostigil (1-10 µM) demonstrates neuroprotective effects by preventing the decline in mitochondrial membrane potential (ψ), reducing apoptotic cascades, and inhibiting the production of reactive oxygen species (ROS) induced by OS insults.[6] Ladostigil (1-10 µM) exhibits notable neuroprotective effects in human neuroblastoma SK-N-SH cells. These effects involve the inhibition of caspase-3 activation, upregulation of Bcl-2 expression, and downregulation of Bad and Bax gene and protein expression.[6] |
| In vivo | Ladostigil (17 mg/kg; p.o. daily for 6 weeks) eliminates hyperanxiety and depressive-like behavior in adult rats exposed to prenatal stress, as shown in the elevated plus maze (EPM) and forced swim tests (FST).[8] Ladostigil (50 μmol/kg; single p.o.) also restores episodic memory in the object recognition test in rats.[7] |
| Alias | TV-3326, TV3326, TV 3326, Ladostigil free base, Ladostigil |
| Molecular Weight | 272.34 |
| Formula | C16H20N2O2 |
| Cas No. | 209394-27-4 |
| Smiles | N(CC#C)[C@H]1C=2C(CC1)=CC=C(OC(N(CC)C)=O)C2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.8 mg/mL (17.63 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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