4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His)

Catalog No. TMPJ-00144

Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation. 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 55-75 KDa and the accession number is Q07011.

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His)

Catalog No. TMPJ-00144

Pack Size	Price	Availability
10 μg	116 €	7-10 days
50 μg	246 €	7-10 days
500 μg	1.520 €	7-10 days
1 mg	2.479 €	7-10 days

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Product Information

Biological Activity	1. Loaded Human 4-1BB-Fc-His on HIS1K Biosensor, can bind Anti-Human CD137 mAb with an affinity constant of 12.2 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human 4-1BB-Fc-His at 2μg/ml (100 μl/well)can bind Anti-Human CD137 mAb. The ED50 of Anti-Human CD137 mAb is 0.41ug/ml. (Regularly tested)
Description	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation. 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 55-75 KDa and the accession number is Q07011.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc-6xHis
Accession Number	Q07011
Synonyms	TNFRSF9,T-cell antigen ILA,T-cell antigen 4-1BB homolog,ILA,CDw137,CD137,4-1BB ligand receptor
Amino Acid	Leu24-Gln186
Construction	Leu24-Gln186
Molecular Weight	55-75 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation.