CD58 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-03408

CD58 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is Q9BRW0.

CD58 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-03408

CD58 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is Q9BRW0.

Pack Size	Price	Availability	Quantity
100 μg	$700	7-10 days
1 mg	$4,570	7-10 days

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Product Information

Biological Activity	1. Measured by its binding ability in a functional ELISA. Immobilized human CD2-His at 10 μg/ml (100 μl/well) can bind human CD58-Fc, The EC50 of human CD58-Fc is 0.04-0.1 μg/ml. 2. Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD2-His at 10 μg/ml (100 μl/well) can bind human CD58-Fc, The EC50 of human CD58-Fc is 0.04-0.10 μg/ml.
Description	CD58 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is Q9BRW0.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q9BRW0
Synonyms	LFA-3,LFA3,CD58 molecule,CD58,ag3
Construction	A DNA sequence encoding the human CD58 (Q9BRW0) (Met1-Arg215) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Phe 29
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	48.5 kDa (predicted); 68 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy