Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD58-His at 10 μg/ml (100 μl/well) can bind Cynomolgus CD2-Fc , The EC50 of Cynomolgus CD2-Fc is 0.06-0.14 μg/ml.

CD58 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23 kDa and the accession number is F7HQR6.

Cynomolgus

HEK293 Cells

LFA3,CD58 molecule,CD58

A DNA sequence encoding the cynomolgus CD58 (F7HQR6) (Met1-Arg215) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ile 29

> 95 % as determined by SDS-PAGE

A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy