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TREM-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Catalog No. TMPY-07192

TREM-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is Q99NH8-1.

TREM-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated

TREM-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Catalog No. TMPY-07192
TREM-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is Q99NH8-1.
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20 μg $588Backorder
100 μg $1,380Backorder
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Product Information

Biological Activity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
TREM-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is Q99NH8-1.
Species
Mouse
Expression System
HEK293 Cells
TagC-His-Avi
Accession NumberQ99NH8-1
Synonyms
Trem2c,Trem2b,Trem2a,TREM-2,Trem2
Construction
A DNA sequence encoding the Mouse TREM2 (NP_112544.1)(Met1-Ser171) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Protein Purity
≥ 95% as determined by SDS-PAGE. ≥ 90% as determined by SEC-HPLC.
Molecular Weight20.06 kDa (predicted); 39.2 kDa (reducing contition)
Endotoxin< 1.0 EU per μg protein as determined by the LAL method.
FormulationLyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Please refer to the lot-specific COA.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.

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Please read the User Guide of Recombinant Proteins for more specific information.