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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $228 | In Stock | |
100 μg | $405 | 7-10 days | |
200 μg | $716 | 7-10 days | |
500 μg | $1,520 | 7-10 days |
Biological Information | Testing in progress |
Description | LILRB1/CD85j/ILT2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.9 kDa and the accession number is D9IDM8. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-hFc |
Accession Number | D9IDM8 |
Synonyms | ILT-2,LIR-1,CD85j,LIR1,MIR7,leukocyte immunoglobulin like receptor B1,ILT2,XXbac-BCX85G21.4,MIR-7 |
Construction | The Human LILRB1 (ADJ55949.1) (Met1-His458) was expressed with the Fc region of Human IgG1 at the C-terminus. |
Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ![]() ![]() |
Molecular Weight | 73.9 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) is a Protein Coding gene. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB1 is encoded within the leukocyte receptor complex on 19q13.4, previously implicated to be a susceptibility region to systemic lupus erythematosus (SLE). LILRB1 binds to a wide range of Major Histocompatibility Complex Class I molecules (MHCIs) and transduces negative signals that can, for example, prevent the killing of MHCI-expressing cells. LILRB1 transcription is correlated with surface protein expression on NK cells. Diseases associated with LILRB1 include Alzheimer's Disease 12 and Severe Pre-Eclampsia. |
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