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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $420 | In Stock | |
5 mg | $596 | In Stock | |
10 mg | $828 | In Stock | |
25 mg | $1,410 | In Stock | |
50 mg | $2,115 | In Stock |
Description | Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors. |
In vitro | In LM8 and Dunn cells, Eribulin inhibited cell proliferation in a dose-dependent manner at concentrations of 0, 1, 10, and 100 nM for 72 hours[1]. |
In vivo | In 4-week-old C3H/HeN mice injected with LM8 cells, Eribulin (1 mg/kg; intravenous injection, once a week for 2 weeks) suppressed primary tumor growth and induced apoptosis in tumor cells. It also reduced the occurrence of lung metastasis and led to a decrease in body weight[1]. |
Alias | ER-086526, E7389, B1939 |
Molecular Weight | 729.90 |
Formula | C40H59NO11 |
Cas No. | 253128-41-5 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (137.01 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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