Immobilized CD27 Protein, Human, Recombinant (His) (Cat#TMPY-03401) at 2 μg/mL (100 μL/well) can bind CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) (Cat#TMPY-07034), the EC50 is 2-6 ng/mL.

CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P32970-1.

≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.

CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy