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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $228 | In Stock | |
100 μg | $405 | 7-10 days | |
200 μg | $716 | 7-10 days | |
500 μg | $1,520 | 7-10 days |
Biological Information | 1. Immobilized LAG3 Protein, Cynomolgus, Recombinant (74 Pro, His Tag) at 2 μg/mL (100 μL/well) can bind FGL1 Protein, Cynomolgus, Recombinant (hFc Tag), the EC50 is 140-760 ng/mL.
2. Immobilized Recombinant Cynomolgus LAG3/CD223(74 Pro,His Tag) at 2μg/mL (100μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody , the EC50 is 60-180 ng/mL. ![]() ![]() |
Description | LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.4 kDa and the accession number is XP_005570011.1. |
Species | Cynomolgus |
Expression System | HEK293 Cells |
Tag | C-His |
Accession Number | XP_005570011.1 |
Synonyms | lymphocyte-activation gene 3 |
Construction | The cynomolgus LAG3 (XP_005570011.1) (Met1-Leu450, 74 Pro) was expressed with a polyhistidine tag at the C-terminus. |
Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. ![]() ![]() |
Molecular Weight | 47.4 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
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