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Cilastatin

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Purity:99.71%

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COA HNMR HPLC

Cilastatin

Catalog No. T2583Cas No. 82009-34-5

Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

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Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$37	In Stock
25 mg	$57	In Stock
50 mg	$81	In Stock
100 mg	$126	In Stock
200 mg	$198	In Stock
500 mg	$343	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Targets&IC50	Renal dehydropeptidase I:0.1 μM (IC50), Metallob-lactamase enzyme CphA (bacterial):178 μM (IC50)
Alias	MK0791

Chemical Properties

Molecular Weight	358.45
Formula	C16H26N2O5S
Cas No.	82009-34-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (125.54 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7898 mL	13.9489 mL	27.8979 mL	139.4895 mL
5 mM	0.5580 mL	2.7898 mL	5.5796 mL	27.8979 mL
10 mM	0.2790 mL	1.3949 mL	2.7898 mL	13.9489 mL
20 mM	0.1395 mL	0.6974 mL	1.3949 mL	6.9745 mL
50 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7898 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3949 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify

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