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SDH-IN-3
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Catalog No. T79238Cas No. 2805297-11-2
SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with potent antifungal activity, demonstrating an inhibition concentration (IC50) of 7.2 μg/mL and an effective concentration (EC50) of 1.9 μg/mL against Nigrospora oryzae, making it valuable for anti-infection research [1].
SDH-IN-3
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Catalog No. T79238Cas No. 2805297-11-2
SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with potent antifungal activity, demonstrating an inhibition concentration (IC50) of 7.2 μg/mL and an effective concentration (EC50) of 1.9 μg/mL against Nigrospora oryzae, making it valuable for anti-infection research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with potent antifungal activity, demonstrating an inhibition concentration (IC50) of 7.2 μg/mL and an effective concentration (EC50) of 1.9 μg/mL against Nigrospora oryzae, making it valuable for anti-infection research [1]. |
| In vitro | SDH-IN-3 (Compound T6) at a concentration of 40 μg/mL for 6-7 days exhibited a prophylactic effect of 81.5% and a curative effect of 43.0% against N. oryzae mycelia infection in rice [1]. Additionally, SDH-IN-3 in the range of 0-40 μg/mL over 14-80 hours significantly inhibited the growth of N. oryzae mycelia, as well as effectively impeding spore germination and germ tube elongation [1]. Furthermore, SDH-IN-3 at 0-20 μg/mL for 12-36 hours compromised the membrane integrity of N. oryzae mycelia by increasing cellular membrane permeability and causing lipid peroxidation [1]. |
| Molecular Weight | 319.33 |
| Formula | C15H11F2N3OS |
| Cas No. | 2805297-11-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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