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Resistomycin
🥰Excellent
Catalog No. T21820Cas No. 20004-62-0
Alias Heliomycin, Geliomycin
Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.
Resistomycin
🥰Excellent
Purity: 99.02%
Catalog No. T21820Alias Heliomycin, GeliomycinCas No. 20004-62-0
Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $109 | In Stock | |
| 2 mg | $155 | In Stock | |
| 5 mg | $251 | In Stock | |
| 10 mg | $371 | In Stock | |
| 25 mg | $593 | In Stock | |
| 50 mg | $798 | In Stock | |
| 100 mg | $1,060 | In Stock | |
| 200 mg | $1,430 | In Stock |
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CitedSelect Batch
Purity:99.02%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis. |
| In vitro | Resistomycin effectively impedes the advancement of triple-negative breast cancer (TNBC) by targeting and inhibiting E3 ligase Pellino-1, which leads to the degradation of SNAIL/SLUG proteins. It binds strongly to GST-Pellino-1, with a dissociation constant (KD) of 2.58 μM, as demonstrated through surface plasmon resonance [1]. Additionally, Resistomycin administration has been shown to decrease SNAIL and SLUG protein levels in TNBC cells [1]. Furthermore, it has been found to provoke apoptosis and cell cycle arrest in human hepatocellular carcinoma cells by activating the p38 MAPK pathway, both in laboratory settings and in animal models [2]. |
| Alias | Heliomycin, Geliomycin |
| Molecular Weight | 376.36 |
| Formula | C22H16O6 |
| Cas No. | 20004-62-0 |
| Smiles | Cc1cc(O)c2C(=O)c3c(O)cc(O)c4C(=O)C(C)(C)c5cc(O)c1c2c5-c34 |
| Relative Density. | 1.2465 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 3.33 mg/mL (8.86 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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