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Novobiocin
🥰Excellent
Catalog No. T20510Cas No. 303-81-1
Alias U-6391, U6391, U 6391, Cathomycin, Albamycin
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections.
Novobiocin
🥰Excellent
Purity: 98.72%
Catalog No. T20510Alias U-6391, U6391, U 6391, Cathomycin, AlbamycinCas No. 303-81-1
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $81 | In Stock | |
| 25 mg | $133 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $293 | In Stock |
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Purity:98.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections. |
| In vitro | Novobiocin (1 mM) competitively hinders the binding of ATP to gyrase B, disrupting nucleotide binding, and impairs the interaction between the co-chaperones Hsc70 and p23 with Hsp90.[1] Novobiocin (200 µM; 24 h) results in the inhibition of the repair rate of DNA interstrand cross-links induced by both cisplatin (cis-DDP) and BCNU. This is accompanied by a corresponding reduction in the clonogenic survival of human glioblastoma multiforme cells.[2] Novobiocin (0.3 mM; 48 hours) triggers caspase-3/7 enzyme-dependent apoptosis assays, resulting in an approximate three- to fivefold increase in the number of apoptotic cells in K562, HL60, and Mutz-2.[5] |
| In vivo | Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24, and 48 h after infection; Adult female Swiss mice (30g) with sepsis induced by the penicillin-susceptible strain (AR33118)) exhibits anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.[3] |
| Alias | U-6391, U6391, U 6391, Cathomycin, Albamycin |
| Molecular Weight | 612.62 |
| Formula | C31H36N2O11 |
| Cas No. | 303-81-1 |
| Smiles | CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C |
| Relative Density. | 1.3448 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (89.78 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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