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Linvencorvir

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Purity:99.78%

ee:95.99%

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COA CSFC HPLC LCMS FNMR HNMR

Linvencorvir

Catalog No. T64221Cas No. 1808248-05-6

Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.

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Pack Size	Price	Availability
1 mg	$121	In Stock
5 mg	$313	In Stock
10 mg	$513	In Stock
25 mg	$837	In Stock
50 mg	$1,160	In Stock
100 mg	$1,560	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock

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Product Introduction

Bioactivity

Description	Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.
In vivo	Linvencorvir (RO7049389) (600/1000 mg; oral; Caucasian and Asian, male and female) followed by 100 μg intravenous [13 C]RO7049389. The model performance in predicting the pharmacokinetic profiles of RO7049389 aligned with clinical observations in Caucasians and was also successfully applied to Asians. Accordingly, the drug disposition pathways for RO7049389 were postulated with newly characterized estimates of the fractions: biliary excretion by P-glycoprotein (~41%), direct glucuronidation via uridine 5'-diphosphoglucuronosyltransferase 1A3 (~11%), hexose conjugation (~6%), oxidation by CYP3A4 (~28%) and other oxidation reactions (~9%). These results support the ongoing clinical development program for RO7049389 and highlight the broader value of PBPK and MB analyses in drug development.[3]
Alias	RG7907

Chemical Properties

Molecular Weight	598.69
Formula	C29H35FN6O5S
Cas No.	1808248-05-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (100.22 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6703 mL	8.3516 mL	16.7031 mL	83.5157 mL
5 mM	0.3341 mL	1.6703 mL	3.3406 mL	16.7031 mL
10 mM	0.1670 mL	0.8352 mL	1.6703 mL	8.3516 mL
20 mM	0.0835 mL	0.4176 mL	0.8352 mL	4.1758 mL
50 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6703 mL
100 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.8352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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