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Calcimycin hemicalcium salt

Name: Calcimycin hemicalcium salt
Brand: TargetMol
SKU: T10662
Price: 53 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T10662Cas No. 59450-89-4

Alias Antibiotic A-23187 hemicalcium salt, A-23187 hemicalcium salt

Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.

Calcimycin hemicalcium salt

😃Good

Catalog No. T10662Alias Antibiotic A-23187 hemicalcium salt, A-23187 hemicalcium saltCas No. 59450-89-4

Pack Size	Price	Availability	Quantity
25 mg	$1,520	Backorder

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Product Introduction

Bioactivity

Description	Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.
In vitro	Calcimycin hemicalcium salt mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner [4].
In vivo	Calcimycin hemicalcium salt (2.5 or 7.5 nM; intrapleural) induces protein leakage [5].
Alias	Antibiotic A-23187 hemicalcium salt, A-23187 hemicalcium salt

Chemical Properties

Molecular Weight	1085.322
Formula	C₅₈H₇₂CaN₆O₁₂
Cas No.	59450-89-4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Antibiotic A23187CalcimycinAntibiotic A-23187 hemicalciumCalcimycin hemicalcium saltA-23187 hemicalciumCalcimycin hemicalciumAntibiotic A 23187A-23187A 23187A23187Antibiotic A-23187