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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $328 | In Stock | |
100 mg | $496 | In Stock | |
500 mg | $1,070 | In Stock | |
1 mL x 10 mM (in DMSO) | $71 | In Stock |
Description | BTZ043 is a DprE1 inhibitor with nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. |
In vitro | The inhibition of BTZ-resistant DprE1 followed the trend observed in the MIC measurements, with the C387 g mutant being more resistant to inhibition by PyrBTZ01, PyrBTZ02, and BTZ043 (7- to 9-fold increases in IC50) than the C387S mutant (2.5- to 4-fold increases in IC50). |
In vivo | BTZ-043 was administered at 100 mg/kg (b.i.d., p.o.), and sulfamethoxazole/trimethoprim (SXT), at 100 mg/kg sulfamethoxazole, was used as a positive control. |
Molecular Weight | 431.39 |
Formula | C17H16F3N3O5S |
Cas No. | 1161233-85-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 15 mg/mL (34.77 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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