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Dup-721
🥰Excellent
Catalog No. T38359Cas No. 104421-21-8
DuP-721 is a broad-spectrum, orally active antibacterial agent that inhibits a variety of clinically susceptible and resistant bacteria, particularly [M. tuberculosis].
Dup-721
🥰Excellent
Purity: 98.53%
Catalog No. T38359Cas No. 104421-21-8
DuP-721 is a broad-spectrum, orally active antibacterial agent that inhibits a variety of clinically susceptible and resistant bacteria, particularly [M. tuberculosis].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 2 mg | $46 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $389 | In Stock | |
| 100 mg | $556 | In Stock | |
| 200 mg | $758 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $86 | In Stock |
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Purity:98.53%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DuP-721 is a broad-spectrum, orally active antibacterial agent that inhibits a variety of clinically susceptible and resistant bacteria, particularly [M. tuberculosis]. |
| In vitro | DuP-721 (1.5-4 μg/ml) effectively inhibits both conventional antituberculosis drug-susceptible and -resistant Mycobacterium tuberculosis strains without showing cross-resistance to any tested anti-tuberculosis drugs[1]. It is ineffective against M. avium and M. intracellulare up to 250 μg/ml, but inhibits M. gordonoe and M. fortuitum at 3.9 μg/ml, and M. kansasii and M. scrofulaceum at 1.95 μg/ml and 15.6 μg/ml, respectively[1]. |
| In vivo | DuP-721, the first oxazolidinone showed good activity against M. tuberculosis when given orally or parenterally to experimental animals. DuP-721 (oral gavage; 50-160 mg/kg) is protective against M. tuberculosis infection in mice. DuP-721 protects 100% of the infected animals at 50 mg/kg p.o. dose when administered daily for 17 days, and the same effect is observed at 160 mg/kg dose when the drug is administered only on day 11 and 12 post infection[1]. |
| Molecular Weight | 276.29 |
| Formula | C14H16N2O4 |
| Cas No. | 104421-21-8 |
| Smiles | CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)C(C)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (354.70 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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