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Ascamycin
🥰Excellent
Catalog No. T14329Cas No. 91432-48-3
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It exhibits selective antibacterial activity against Xanthomonas species, inhibiting Xanthomonas citri, Xanthomonas oryzae, and phage with MIC values of 0.4 μg/mL, 12.5 μg/mL, and 12.5 μg/mL respectively.
Ascamycin
🥰Excellent
Purity: 99%
Catalog No. T14329Cas No. 91432-48-3
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It exhibits selective antibacterial activity against Xanthomonas species, inhibiting Xanthomonas citri, Xanthomonas oryzae, and phage with MIC values of 0.4 μg/mL, 12.5 μg/mL, and 12.5 μg/mL respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 332 € | In Stock | |
| 5 mg | 786 € | In Stock | |
| 10 mg | 1.073 € | In Stock | |
| 25 mg | 1.510 € | In Stock | |
| 50 mg | 1.881 € | In Stock | |
| 100 mg | 2.375 € | In Stock | |
| 500 mg | 4.655 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 746 € | In Stock |
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It exhibits selective antibacterial activity against Xanthomonas species, inhibiting Xanthomonas citri, Xanthomonas oryzae, and phage with MIC values of 0.4 μg/mL, 12.5 μg/mL, and 12.5 μg/mL respectively. |
| Targets&IC50 | Xanthomonas citri:（MIC）0.4 μg/ml, Xanthomonas oryzae:12.5 μg/ml, Mycobacterium phlei:12.5 μg/ml, Mycobacterium phlei:12.5 μg/ml(MIC), Xanthomonas oryzae:12.5 μg/ml(MIC), Xanthomonas citri:0.4 μg/ml(MIC) |
| In vitro | Ascamycin has a selective antibacterial activity against Xanthomonas species and it has C2-chloroadenine as the base on C-1' which lacks the chlorine.[1] Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface, When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria.[2] |
| Molecular Weight | 451.84 |
| Formula | C13H18ClN7O7S |
| Cas No. | 91432-48-3 |
| Smiles | NC1=C2C(N(C=N2)[C@@H]3O[C@H](COS(NC([C@H](C)N)=O)(=O)=O)[C@@H](O)[C@H]3O)=NC(Cl)=N1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (22.13 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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