Cefuroxime (Cephuroxime) is an orally active second-generation cephalosporin antibiotic with antimicrobial activity that inhibits both Gram-positive and Gram-negative bacteria, and is used in the study of soft tissue infections.

methicillin-resistant Staphylococcus aureus:5.9 μg/ml (MIC), Streptococcus viridans:0.125 μg/ml (MIC), S. aureus:0.25 μg/mL (MIC), methicillin-susceptible Staphylococcus aureus:0.25 μg/ml (MIC), Enterococcus faecalis:>125.0 μg/ml (MIC), Clostridium difficile:1.2 μg/ml (MIC), Streptococcus pneumoniae:0.125 μg/ml (MIC), Streptococcus pyogenes:0.125 μg/ml (MIC)

Regardless of whether S. aureus produces penicillinase or not, Cefuroxime showed strong antibacterial activity with a minimum inhibitory concentration (MIC) of 0.25 μg/ml.It exhibited significant antibacterial activity against methicillin-sensitive S. aureus, methicillin-resistant S. aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, and Clostridium difficile. antimicrobial effect with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml and 1.2 μg/ml, respectively.
Cefuroxime (10-100 μg/ml, 2-6 hours of action) is rapidly bactericidal. Although it is relatively slow against S. aureus strains, it kills more than 99% of the initial inoculum within 6 hours. For Gram-negative bacteria, Cefuroxime is even faster, killing more than 99% of highly inoculated strains in just 2 hours in most cases. There is no significant difference in the speed of sterilization between β-lactamase-producing and non-enzyme-producing strains. [1]

In rabbits (2.0 to 2.5 kg body weight) infected with 630 strains of penicillinase-producing Staphylococcus aureus by intravenous injection, a protection test showed a median effective dose of Cefuroxime of 3 mg/kg. [2]