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Rebeccamycin
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Catalog No. T16726Cas No. 93908-02-2
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
Rebeccamycin
😃Good
Catalog No. T16726Cas No. 93908-02-2
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $445 | 35 days | |
| 2500 μg | $1,980 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II. |
| In vitro | Rebeccamycin produced by the actinomycete Saccharotrix aerocolonigenes. It has activity against several human tumor cell lines, including lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma. Rebeccamycin displays antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis [1][3]. |
| In vivo | Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) extends survival in B16 melanoma and L1210 leukemia[2]. |
| Molecular Weight | 570.38 |
| Formula | C27H21Cl2N3O7 |
| Cas No. | 93908-02-2 |
| Relative Density. | 1.87g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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