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Acivicin
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Catalog No. T14114Cas No. 42228-92-2
Alias U-42126, U42126, U 42126, AT-125, AT125, AT 125
Acivicin (AT-125), a chlorinated amino acid antibiotic produced by Streptomyces porcineus, is a γ-glutamyl transpeptidase (GGT) inhibitor that crosses the blood-brain barrier, exhibits anticancer and antiparasitic activity, and is used in the study of visceral leishmaniasis.
Acivicin
😃Good
Catalog No. T14114Alias U-42126, U42126, U 42126, AT-125, AT125, AT 125Cas No. 42228-92-2
Acivicin (AT-125), a chlorinated amino acid antibiotic produced by Streptomyces porcineus, is a γ-glutamyl transpeptidase (GGT) inhibitor that crosses the blood-brain barrier, exhibits anticancer and antiparasitic activity, and is used in the study of visceral leishmaniasis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $125 | 35 days | |
| 5 mg | $490 | 35 days | |
| 10 mg | $690 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Acivicin (AT-125), a chlorinated amino acid antibiotic produced by Streptomyces porcineus, is a γ-glutamyl transpeptidase (GGT) inhibitor that crosses the blood-brain barrier, exhibits anticancer and antiparasitic activity, and is used in the study of visceral leishmaniasis. |
| In vivo | In male pigmented Long-Evans rats weighing between 250 g and 300 g exposed to toluene, Acivicin (5 mg/kg; intraperitoneal injection; twice weekly) was able to reduce urinary γ-GT by 70-78%[3]. |
| Alias | U-42126, U42126, U 42126, AT-125, AT125, AT 125 |
| Molecular Weight | 178.57 |
| Formula | C5H7ClN2O3 |
| Cas No. | 42228-92-2 |
| Smiles | N[C@@H]([C@@H]1CC(Cl)=NO1)C(O)=O |
| Relative Density. | 1.85 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 4 mg/mL (22.40 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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