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Acivicin hydrochloride
🥰Excellent
Catalog No. T77207Cas No. 161922-40-3
Alias U-42126 hydrochloride, U42126 hydrochloride, AT-125 hydrochloride, AT125 hydrochloride
Acivicin hydrochloride is the hydrochloride form of Acivicin (AT125, U42126).Acivicin, a natural product from Streptomyces sviceus (Streptomyces), is a glutamine analog and a potent inhibitor of γ-glutamyltransferase (GGT) and a potent inhibitor of l -Asparagine synthetase and other l-glutamine aminotransferases, and is cytotoxic by blocking nucleotide biosynthesis.
Acivicin hydrochloride
🥰Excellent
Purity: 99.14%
Catalog No. T77207Alias U-42126 hydrochloride, U42126 hydrochloride, AT-125 hydrochloride, AT125 hydrochlorideCas No. 161922-40-3
Acivicin hydrochloride is the hydrochloride form of Acivicin (AT125, U42126).Acivicin, a natural product from Streptomyces sviceus (Streptomyces), is a glutamine analog and a potent inhibitor of γ-glutamyltransferase (GGT) and a potent inhibitor of l -Asparagine synthetase and other l-glutamine aminotransferases, and is cytotoxic by blocking nucleotide biosynthesis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $196 | In Stock |
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Purity:99.14%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Acivicin hydrochloride is the hydrochloride form of Acivicin (AT125, U42126).Acivicin, a natural product from Streptomyces sviceus (Streptomyces), is a glutamine analog and a potent inhibitor of γ-glutamyltransferase (GGT) and a potent inhibitor of l -Asparagine synthetase and other l-glutamine aminotransferases, and is cytotoxic by blocking nucleotide biosynthesis. |
| In vitro | Methods: HepG2 cells were treated with Acivicin hydrochloride (0.1-50 μM, 5 days) and cell viability was measured. Results: Its IC50 value in HepG2 cells was 0.7 μM. [1] |
| Alias | U-42126 hydrochloride, U42126 hydrochloride, AT-125 hydrochloride, AT125 hydrochloride |
| Molecular Weight | 215.04 |
| Formula | C5H8Cl2N2O3 |
| Cas No. | 161922-40-3 |
| Smiles | [C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H].Cl |
Storage & Solubility Information
| Storage | store under nitrogen | store at 4°C | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (372.02 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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