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Troleandomycin
🥰Excellent
Catalog No. T21148Cas No. 2751-09-9
Alias Triacetyloleandomycin, Micotil, Matromycin T, Cyclamycin, Aovine, AI3-50166
Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma.
Troleandomycin
🥰Excellent
Purity: 98.00%
Catalog No. T21148Alias Triacetyloleandomycin, Micotil, Matromycin T, Cyclamycin, Aovine, AI3-50166Cas No. 2751-09-9
Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $499 | In Stock | |
| 2 mg | $599 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma. |
| In vitro | Troleandomycin significantly inhibits microsomal side chain hydroxylation in mouse and human livers in a dose-dependent manner. [1] |
| In vivo | Troleandomycin significantly inhibits the 6β-hydroxylation of testosterone, the 25- and 26-hydroxylation of 5β-cholestane-3α, 7α, and 12α-triol, and the 23R-, 24R-, 24R-, 5β-cholestane-3α, 7α 24S- and 27-hydroxylation, 12α, 25-tetrol in recombinant CYP3A4 and microsomes, but the IC50 value of microsomes is slightly higher than that of recombinant CYP3A4.[2] |
| Alias | Triacetyloleandomycin, Micotil, Matromycin T, Cyclamycin, Aovine, AI3-50166 |
| Molecular Weight | 813.97 |
| Formula | C41H67NO15 |
| Cas No. | 2751-09-9 |
| Smiles | [H][C@@]1(C[C@H](OC)[C@@H](OC(C)=O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2OC(C)=O)N(C)C)[C@@H](C)C[C@@]2(CO2)C(=O)[C@H](C)[C@@]([H])(OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]1C |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (61.43 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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